In the development of vaccines against coronaviruses like SARS-COV-1 and MERS in the early 2000’s, researchers found evidence of a serious problem. Teams of U.S. and foreign scientists vaccinated animals with the four most promising vaccines. At first, the experiment seemed successful as all the animals developed a robust antibody response to coronavirus. However, when the scientists exposed the vaccinated animals to the wild virus, the results were horrifying. Vaccinated animals suffered hyper-immune responses including inflammation throughout their bodies, especially in their lungs.
This issue is well known. Early in the COVID-19 scenario, Dr. Peter Hotez, of Baylor College of Medicine, testified before Congress about the dangers of accelerating coronavirus vaccine development, saying “(The) unique safety problem of coronavirus vaccines” was discovered 50 years ago while developing the Respiratory Syncytial Virus (RSV) vaccine.”
He went to register that this “‘paradoxical immune enhancement phenomenon’ means vaccinated people may still develop the disease, get sicker and die.”
Researchers had seen this same “enhanced immune response” during human testing of the failed RSV vaccine tests in the 1950s. The vaccines not only failed to prevent infection; 80% of the children infected required hospitalization, and two children challenged with the RSV died (see Openshaw, 2005). In April of 2020, Hotez told CNN, “If there is immune enhancement in animals, that’s a showstopper.”